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Prion pathogenesis is unaltered following down-regulation of SIGN-R1

Prion diseases are infectious neurodegenerative disorders characterised by accumulations of abnormal prion glycoprotein in affected tissues. Following peripheral exposure, many prion strains replicate upon follicular dendritic cells (FDC) in lymphoid tissues before infecting the brain. An intact spl...

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Detalles Bibliográficos
Autores principales: Bradford, Barry M., Brown, Karen L., Mabbott, Neil A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031137/
https://www.ncbi.nlm.nih.gov/pubmed/27522473
http://dx.doi.org/10.1016/j.virol.2016.08.005