Cargando…

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling

The linear ubiquitin chain assembly complex (LUBAC) regulates immune signaling, and its function is regulated by the deubiquitinases OTULIN and CYLD, which associate with the catalytic subunit HOIP. However, the mechanism through which CYLD interacts with HOIP is unclear. We here show that CYLD inte...

Descripción completa

Detalles Bibliográficos
Autores principales:	Elliott, Paul R., Leske, Derek, Hrdinka, Matous, Bagola, Katrin, Fiil, Berthe K., McLaughlin, Stephen H., Wagstaff, Jane, Volkmar, Norbert, Christianson, John C., Kessler, Benedikt M., Freund, Stefan M.V., Komander, David, Gyrd-Hansen, Mads
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031558/ https://www.ncbi.nlm.nih.gov/pubmed/27591049 http://dx.doi.org/10.1016/j.molcel.2016.08.001

Ejemplares similares

Molecular Basis and Regulation of OTULIN-LUBAC Interaction
por: Elliott, Paul R., et al.
Publicado: (2014)

CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling
por: Hrdinka, Matous, et al.
Publicado: (2016)

OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin
por: Keusekotten, Kirstin, et al.
Publicado: (2013)

Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
por: Elliott, Paul R., et al.
Publicado: (2021)

SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes
por: Kupka, Sebastian, et al.
Publicado: (2016)

LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes
por: Draber, Peter, et al.
Publicado: (2015)

LUBAC: A new function in immunity
por: Boisson, Bertrand, et al.
Publicado: (2014)

Henri de Lubac : la obra orgánica de una vida
por: Balthasar, Hans Urs von, 1905-1988
Publicado: (1989)

CYLD in health and disease
por: Marín-Rubio, José L., et al.
Publicado: (2023)

LUBAC: a new player in polyglucosan body disease
por: Aboujaoude, Andrew, et al.
Publicado: (2021)

SPATA2 and CYLD inhibit T cell infiltration into colorectal cancer via regulation of IFN-γ/STAT1 axis
por: Tan, Tze Guan, et al.
Publicado: (2022)

LUBAC synthesizes linear ubiquitin chains via a thioester intermediate
por: Stieglitz, Benjamin, et al.
Publicado: (2012)

Ripk1 and haematopoiesis: a case for LUBAC and Ripk3
por: Annibaldi, Alessandro, et al.
Publicado: (2018)

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis
por: Peltzer, Nieves, et al.
Publicado: (2018)

LUBAC determines chemotherapy resistance in squamous cell lung cancer
por: Ruiz, E. Josue, et al.
Publicado: (2019)

CYLD and SUMO in neuroblastoma therapy
por: Masoumi, Katarzyna Chmielarska, et al.
Publicado: (2016)

UVB radiation represses CYLD expression in melanocytes
por: Kuphal, Silke, et al.
Publicado: (2017)

A novel large deletion of the CYLD gene causes CYLD cutaneous syndrome in a Chinese family
por: Zhu, Ruizheng, et al.
Publicado: (2020)

The linear ubiquitin chain assembly complex (LUBAC) generates heterotypic ubiquitin chains
por: Rodriguez Carvajal, Alan, et al.
Publicado: (2021)

OTULIN deficiency in ORAS causes cell type‐specific LUBAC degradation, dysregulated TNF signalling and cell death
por: Damgaard, Rune Busk, et al.
Publicado: (2019)

Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia
por: Boisson, Bertrand, et al.
Publicado: (2015)

LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis
por: Matsunaga, Yasuka, et al.
Publicado: (2015)

LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation
por: Zinngrebe, Julia, et al.
Publicado: (2016)

LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores
por: Wu, Min, et al.
Publicado: (2019)

Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses
por: Oikawa, Daisuke, et al.
Publicado: (2020)

LUBAC-mediated linear ubiquitination: a crucial regulator of immune signaling
por: IWAI, Kazuhiro
Publicado: (2021)

Global Screening of LUBAC and OTULIN Interacting Proteins by Human Proteome Microarray
por: Zhou, Lijie, et al.
Publicado: (2021)

CYLD tumour supressor regulates ciligenesis
por: Eguether, T, et al.
Publicado: (2012)

The tumour suppressor CYLD regulates the p53 DNA damage response
por: Fernández-Majada, Vanesa, et al.
Publicado: (2016)

The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation
por: Rodgers, Mary A., et al.
Publicado: (2014)

Immunodeficiency, auto-inflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency
por: Boisson, Bertrand, et al.
Publicado: (2012)

Corrigenda to “LUBAC-mediated linear ubiquitination: a crucial regulator of immune signaling”
por: IWAI, Kazuhiro
Publicado: (2021)

LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole
por: Shen, Xiao-Lin, et al.
Publicado: (2021)

The cylindromatosis (CYLD) gene and head and neck tumorigenesis
por: Verhoeft, Krista Roberta, et al.
Publicado: (2016)

Genetic Testing in CYLD Cutaneous Syndrome: An Update
por: Nagy, Nikoletta, et al.
Publicado: (2021)

Gynaecological cylindroma in association with CYLD gene mutation
por: Khoury, Emma, et al.
Publicado: (2022)

Genotoxicity-Stimulated and CYLD-Driven Malignant Transformation
por: Erol, Adnan
Publicado: (2022)

Impact of CYLD on chromatin structure and histone methylation in malignant melanoma
por: Schott, Mandy, et al.
Publicado: (2022)

Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination
por: de Almagro, M C, et al.
Publicado: (2015)

Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy
por: Miyashita, Hirohisa, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9su2qf5plb091eqg12s5u5qsdi