The model homologue of the partially defective human 5,10-methylenetetrahydrofolate reductase, considered as a risk factor for stroke due to increased homocysteine level, can be protected and reactivated by heat shock proteins

The A222 V substitution in the human MTHFR gene product (5,10-methylenetetrahydrofolate reductase) is responsible for a decreased activity of this enzyme. This may cause an increased homocysteine level, considered as a risk factor for arteriosclerosis and stroke. The bacterial homologue of the human...

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Detalles Bibliográficos
Autores principales: Grabowski, Michał, Banecki, Bogdan, Kadziński, Leszek, Jakóbkiewicz-Banecka, Joanna, Gabig-Cimińska, Magdalena, Węgrzyn, Alicja, Węgrzyn, Grzegorz, Banecka-Majkutewicz, Zyta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031757/
https://www.ncbi.nlm.nih.gov/pubmed/27234992
http://dx.doi.org/10.1007/s11011-016-9844-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031757/
https://www.ncbi.nlm.nih.gov/pubmed/27234992
http://dx.doi.org/10.1007/s11011-016-9844-8

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