P-glycoprotein (ABCB1) activity decreases raltegravir disposition in primary CD4+P-gp(high) cells and correlates with HIV-1 viral load

OBJECTIVES: To evaluate the role of P-glycoprotein (P-gp) and multidrug-resistant-protein 1 (MRP1) on raltegravir intracellular drug disposition in CD4+ T cells, investigate the effect of HIV-1 infection on P-gp expression and correlate HIV-1 viraemia with P-gp activity in primary CD4+ T cell subset...

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Detalles Bibliográficos
Autores principales: Minuesa, Gerard, Arimany-Nardi, Cristina, Erkizia, Itziar, Cedeño, Samandhy, Moltó, José, Clotet, Bonaventura, Pastor-Anglada, Marçal, Martinez-Picado, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031918/
https://www.ncbi.nlm.nih.gov/pubmed/27334660
http://dx.doi.org/10.1093/jac/dkw215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031918/
https://www.ncbi.nlm.nih.gov/pubmed/27334660
http://dx.doi.org/10.1093/jac/dkw215

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