Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration

Mutations in optineurin (OPTN) are linked to the pathology of primary open angle glaucoma (POAG) and amyotrophic lateral sclerosis. Emerging evidence indicates that OPTN mutation is involved in accumulation of damaged mitochondria and defective mitophagy. Nevertheless, the role played by an OPTN E50...

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Detalles Bibliográficos
Autores principales: Shim, Myoung Sup, Takihara, Yuji, Kim, Keun-Young, Iwata, Takeshi, Yue, Beatrice Y. J. T., Inatani, Masaru, Weinreb, Robert N., Perkins, Guy A., Ju, Won-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031982/
https://www.ncbi.nlm.nih.gov/pubmed/27654856
http://dx.doi.org/10.1038/srep33830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031982/
https://www.ncbi.nlm.nih.gov/pubmed/27654856
http://dx.doi.org/10.1038/srep33830

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