Identification of hepta-histidine as a candidate drug for Huntington’s disease by in silico-in vitro- in vivo-integrated screens of chemical libraries

We identified drug seeds for treating Huntington’s disease (HD) by combining in vitro single molecule fluorescence spectroscopy, in silico molecular docking simulations, and in vivo fly and mouse HD models to screen for inhibitors of abnormal interactions between mutant Htt and physiological Ku70, a...

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Detalles Bibliográficos
Autores principales: Imamura, Tomomi, Fujita, Kyota, Tagawa, Kazuhiko, Ikura, Teikichi, Chen, Xigui, Homma, Hidenori, Tamura, Takuya, Mao, Ying, Taniguchi, Juliana Bosso, Motoki, Kazumi, Nakabayashi, Makoto, Ito, Nobutoshi, Yamada, Kazunori, Tomii, Kentaro, Okano, Hideyuki, Kaye, Julia, Finkbeiner, Steven, Okazawa, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032119/
https://www.ncbi.nlm.nih.gov/pubmed/27653664
http://dx.doi.org/10.1038/srep33861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032119/
https://www.ncbi.nlm.nih.gov/pubmed/27653664
http://dx.doi.org/10.1038/srep33861

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