A conjugate of methotrexate and an analog of luteinizing hormone releasing hormone shows increased efficacy against prostate cancer

LHRH receptor, is over-expressed in a variety of human tumors and, is a potential binding site for targeted metastatic prostate cancer therapy. The objectives of our study were to synthesize a bioconjugate of the LHRH analog [DLys(6)]-LHRH and the anti-tumor agent methotrexate and test the hypothesi...

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Detalles Bibliográficos
Autores principales: Zhu, Shengsheng, Wang, Qinxia, Jiang, Juan, Luo, Yongwei, Sun, Zuyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032167/
https://www.ncbi.nlm.nih.gov/pubmed/27654169
http://dx.doi.org/10.1038/srep33894

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032167/
https://www.ncbi.nlm.nih.gov/pubmed/27654169
http://dx.doi.org/10.1038/srep33894

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