Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

BACKGROUND: Epigenetic change is a hallmark of ageing but its link to ageing mechanisms in humans remains poorly understood. While DNA methylation at many CpG sites closely tracks chronological age, DNA methylation changes relevant to biological age are expected to gradually dissociate from chronolo...

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Detalles Bibliográficos
Autores principales: Slieker, Roderick C., van Iterson, Maarten, Luijk, René, Beekman, Marian, Zhernakova, Daria V., Moed, Matthijs H., Mei, Hailiang, van Galen, Michiel, Deelen, Patrick, Bonder, Marc Jan, Zhernakova, Alexandra, Uitterlinden, André G., Tigchelaar, Ettje F., Stehouwer, Coen D. A., Schalkwijk, Casper G., van der Kallen, Carla J. H., Hofman, Albert, van Heemst, Diana, de Geus, Eco J., van Dongen, Jenny, Deelen, Joris, van den Berg, Leonard H., van Meurs, Joyce, Jansen, Rick, ‘t Hoen, Peter A. C., Franke, Lude, Wijmenga, Cisca, Veldink, Jan H., Swertz, Morris A., van Greevenbroek, Marleen M. J., van Duijn, Cornelia M., Boomsma, Dorret I., Slagboom, P. Eline, Heijmans, Bastiaan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032245/
https://www.ncbi.nlm.nih.gov/pubmed/27654999
http://dx.doi.org/10.1186/s13059-016-1053-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032245/
https://www.ncbi.nlm.nih.gov/pubmed/27654999
http://dx.doi.org/10.1186/s13059-016-1053-6

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