Treatment of spontaneous EAE by laquinimod reduces Tfh, B cell aggregates, and disease progression

OBJECTIVE: To evaluate the influence of oral laquinimod, a candidate multiple sclerosis (MS) treatment, on induction of T follicular helper cells, development of meningeal B cell aggregates, and clinical disease in a spontaneous B cell–dependent MS model. METHODS: Experimental autoimmune encephalomy...

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Detalles Bibliográficos
Autores principales: Varrin-Doyer, Michel, Pekarek, Kara L., Spencer, Collin M., Bernard, Claude C.A., Sobel, Raymond A., Cree, Bruce A.C., Schulze-Topphoff, Ulf, Zamvil, Scott S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032667/
https://www.ncbi.nlm.nih.gov/pubmed/27704036
http://dx.doi.org/10.1212/NXI.0000000000000272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032667/
https://www.ncbi.nlm.nih.gov/pubmed/27704036
http://dx.doi.org/10.1212/NXI.0000000000000272

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