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BMI1 inhibits senescence and enhances the immunomodulatory properties of human mesenchymal stem cells via the direct suppression of MKP-1/DUSP1
For the application of mesenchymal stem cells (MSCs) as clinical therapeutics, the regulation of cellular aging is important to protect hMSCs from an age-associated decline in their function. In this study, we evaluated the effects of hypoxia on cellular senescence and the immunomodulatory abilities...
Autores principales: | Lee, Jin Young, Yu, Kyung-Rok, Kim, Hyung-Sik, Kang, Insung, Kim, Jae-Jun, Lee, Byung-Chul, Choi, Soon Won, Shin, Ji-Hee, Seo, Yoojin, Kang, Kyung-Sun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032689/ https://www.ncbi.nlm.nih.gov/pubmed/27454161 http://dx.doi.org/10.18632/aging.101000 |
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