Biological and biophysics aspects of metformin-induced effects: cortex mitochondrial dysfunction and promotion of toxic amyloid pre-fibrillar aggregates

The onset of Alzheimer disease (AD) is influenced by several risk factors comprising diabetes. Within this context, antidiabetic drugs, including metformin, are investigated for their effect on AD. We report that in the C57B6/J mice, metformin is delivered to the brain where activates AMP-activated...

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Detalles Bibliográficos
Autores principales: Picone, Pasquale, Vilasi, Silvia, Librizzi, Fabio, Contardi, Marco, Nuzzo, Domenico, Caruana, Luca, Baldassano, Sara, Amato, Antonella, Mulè, Flavia, San Biagio, Pier Luigi, Giacomazza, Daniela, Di Carlo, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032692/
https://www.ncbi.nlm.nih.gov/pubmed/27509335
http://dx.doi.org/10.18632/aging.101004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032692/
https://www.ncbi.nlm.nih.gov/pubmed/27509335
http://dx.doi.org/10.18632/aging.101004

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