Cargando…

Biological and biophysics aspects of metformin-induced effects: cortex mitochondrial dysfunction and promotion of toxic amyloid pre-fibrillar aggregates

The onset of Alzheimer disease (AD) is influenced by several risk factors comprising diabetes. Within this context, antidiabetic drugs, including metformin, are investigated for their effect on AD. We report that in the C57B6/J mice, metformin is delivered to the brain where activates AMP-activated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Picone, Pasquale, Vilasi, Silvia, Librizzi, Fabio, Contardi, Marco, Nuzzo, Domenico, Caruana, Luca, Baldassano, Sara, Amato, Antonella, Mulè, Flavia, San Biagio, Pier Luigi, Giacomazza, Daniela, Di Carlo, Marta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032692/ https://www.ncbi.nlm.nih.gov/pubmed/27509335 http://dx.doi.org/10.18632/aging.101004

Ejemplares similares

Data concerning the proteolytic resistance and oxidative stress in LAN5 cells after treatment with BSA hydrogels
por: Picone, Pasquale, et al.
Publicado: (2016)

From Small Peptides to Large Proteins against Alzheimer’sDisease
por: Picone, Pasquale, et al.
Publicado: (2022)

NAFLD and Atherosclerosis Are Prevented by a Natural Dietary Supplement Containing Curcumin, Silymarin, Guggul, Chlorogenic Acid and Inulin in Mice Fed a High-Fat Diet
por: Amato, Antonella, et al.
Publicado: (2017)

Insulin Promotes Survival of Amyloid-Beta Oligomers Neuroblastoma Damaged Cells via Caspase 9 Inhibition and Hsp70 Upregulation
por: Di Carlo, M., et al.
Publicado: (2010)

Infrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation
por: Ruggeri, F. S., et al.
Publicado: (2015)

Valorization of Apple Peels through the Study of the Effects on the Amyloid Aggregation Process of κ-Casein
por: Guarrasi, Valeria, et al.
Publicado: (2021)

Preventive Impact of Long-Term Ingestion of Chestnut Honey on Glucose Disorders and Neurodegeneration in Obese Mice
por: Terzo, Simona, et al.
Publicado: (2022)

Long-Term Ingestion of Sicilian Black Bee Chestnut Honey and/or D-Limonene Counteracts Brain Damage Induced by High Fat-Diet in Obese Mice
por: Terzo, Simona, et al.
Publicado: (2023)

Biochemical and biophysical characterization of pathological aggregation of amyloid proteins
por: Long, Houfang, et al.
Publicado: (2022)

Hydroxytyrosol Inhibits Protein Oligomerization and Amyloid Aggregation in Human Insulin
por: Sirangelo, Ivana, et al.
Publicado: (2020)

β-Carotene, a Potent Amyloid Aggregation Inhibitor, Promotes Disordered Aβ Fibrillar Structure
por: Banerjee, Siddhartha, et al.
Publicado: (2023)

Regular Intake of Pistachio Mitigates the Deleterious Effects of a High Fat-Diet in the Brain of Obese Mice
por: Nuzzo, Domenico, et al.
Publicado: (2020)

Is there a sodium effect in fibrillar amyloid-β oligomers?
por: Horn, Anselm HC, et al.
Publicado: (2014)

Fibrillar Amyloid Plaque Formation Precedes Microglial Activation
por: Jung, Christian K. E., et al.
Publicado: (2015)

Conservation of the Amyloid Interactome Across Diverse Fibrillar Structures
por: Juhl, Dennis Wilkens, et al.
Publicado: (2019)

The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates
por: Morimoto, Daichi, et al.
Publicado: (2015)

Structural polymorphisms in fibrillar aggregates associated with exfoliation syndrome
por: Ghaffari Sharaf, Mehdi, et al.
Publicado: (2020)

A Natural Dietary Supplement with a Combination of Nutrients Prevents Neurodegeneration Induced by a High Fat Diet in Mice
por: Nuzzo, Domenico, et al.
Publicado: (2018)

Recovery from Food Waste—Biscuit Doughs Enriched with Pomegranate Peel Powder as a Model of Fortified Aliment
por: Nuzzo, Domenico, et al.
Publicado: (2022)

Neurological Consequences, Mental Health, Physical Care, and Appropriate Nutrition in Long-COVID-19
por: Picone, Pasquale, et al.
Publicado: (2022)

Small molecule-mediated co-assembly of amyloid-β oligomers reduces neurotoxicity through promoting non-fibrillar aggregation
por: Liu, Hao, et al.
Publicado: (2020)

Stability of single and double layer fibrillar amyloid-β oligomers
por: Kahler, Anna, et al.
Publicado: (2013)

Recombinant Bri3 BRICHOS domain is a molecular chaperone with effect against amyloid formation and non-fibrillar protein aggregation
por: Poska, Helen, et al.
Publicado: (2020)

Post-Acute COVID-19 Neurological Syndrome: A New Medical Challenge
por: Nuzzo, Domenico, et al.
Publicado: (2021)

A European multicentre PET study of fibrillar amyloid in Alzheimer’s disease
por: Nordberg, Agneta, et al.
Publicado: (2012)

Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease
por: Pan, Xiao-dong, et al.
Publicado: (2011)

Data concerning the rheological behavior of high methoxyl pectin during gelation process
por: Giacomazza, Daniela, et al.
Publicado: (2018)

Molecular Structure of Amyloid Fibrils Controls the Relationship between Fibrillar Size and Toxicity
por: Lee, Young Jin, et al.
Publicado: (2011)

Nucleobindin 1 binds to multiple types of pre-fibrillar amyloid and inhibits fibrillization
por: Bonito-Oliva, Alessandra, et al.
Publicado: (2017)

Long-Term Brain Disorders in Post Covid-19 Neurological Syndrome (PCNS) Patient
por: Nuzzo, Domenico, et al.
Publicado: (2021)

The case of encephalitis in a COVID-19 pediatric patient
por: Urso, Lidia, et al.
Publicado: (2021)

Mitochondrial Dysfunction: Different Routes to Alzheimer's Disease Therapy
por: Picone, Pasquale, et al.
Publicado: (2014)

Conformational Targeting of Fibrillar Polyglutamine Proteins in Live Cells Escalates Aggregation and Cytotoxicity
por: Kvam, Erik, et al.
Publicado: (2009)

Bivalent Copper Ions Promote Fibrillar Aggregation of KCTD1 and Induce Cytotoxicity
por: Liu, Zhepeng, et al.
Publicado: (2016)

C5a Increases the Injury to Primary Neurons Elicited by Fibrillar Amyloid Beta
por: Hernandez, Michael X., et al.
Publicado: (2017)

Non-uniform self-assembly: On the anisotropic architecture of α-synuclein supra-fibrillar aggregates
por: Semerdzhiev, Slav A., et al.
Publicado: (2017)

Towards preventing exfoliation glaucoma by targeting and removing fibrillar aggregates associated with exfoliation syndrome
por: Ghaffari Sharaf, Mehdi, et al.
Publicado: (2022)

VIP Enhances Phagocytosis of Fibrillar Beta-Amyloid by Microglia and Attenuates Amyloid Deposition in the Brain of APP/PS1 Mice
por: Song, Min, et al.
Publicado: (2012)

Synaptosomes: new vesicles for neuronal mitochondrial transplantation
por: Picone, Pasquale, et al.
Publicado: (2021)

C5aR agonist enhances phagocytosis of fibrillar and non-fibrillar Aβ amyloid and preserves memory in a mouse model of familial Alzheimer’s disease
por: Panayiotou, Elena, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_8b0l98v9uk2osmu7kgtali9psm