Cargando…

Assessment of the contribution of APOE gene variants to metabolic phenotypes associated with familial longevity at middle age

Offspring of long-lived families are characterized by beneficial metabolic phenotypes in glucose and lipid metabolism and low 25-hydroxyvitamin D. Although the genetic basis for human longevity remains largely unclear, the contribution of variation at the APOE locus has been repeatedly demonstrated....

Descripción completa

Detalles Bibliográficos
Autores principales:	Noordam, Raymond, Oudt, Charlotte H., Deelen, Joris, Slagboom, P. Eline, Beekman, Marian, van Heemst, Diana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032696/ https://www.ncbi.nlm.nih.gov/pubmed/27540764 http://dx.doi.org/10.18632/aging.101017

Ejemplares similares

Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study
por: Mooijaart, Simon P., et al.
Publicado: (2010)

Metabolomic and lipidomic assessment of the metabolic syndrome in Dutch middle-aged individuals reveals novel biological signatures separating health and disease
por: Surowiec, Izabella, et al.
Publicado: (2019)

Identifying the genomic determinants of aging and longevity in human population studies: Progress and challenges
por: Deelen, Joris, et al.
Publicado: (2013)

Human insulin/IGF-1 and familial longevity at middle age
por: Rozing, Maarten P., et al.
Publicado: (2009)

Homocysteine and Familial Longevity: The Leiden Longevity Study
por: Wijsman, Carolien A., et al.
Publicado: (2011)

C-reactive protein and glucose regulation in familial longevity
por: Rozing, Maarten P., et al.
Publicado: (2011)

Familial Longevity Is Marked by Better Cognitive Performance at Middle Age: The Leiden Longevity Study
por: Stijntjes, Marjon, et al.
Publicado: (2013)

Classification for Longevity Potential: The Use of Novel Biomarkers
por: Beekman, Marian, et al.
Publicado: (2016)

Metabolomics analyses in non-diabetic middle-aged individuals reveal metabolites impacting early glucose disturbances and insulin sensitivity
por: Bos, Maxime M., et al.
Publicado: (2020)

Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes
por: van der Kroef, Sabrina, et al.
Publicado: (2016)

Familial Longevity Is Marked by Lower Diurnal Salivary Cortisol Levels: The Leiden Longevity Study
por: Noordam, Raymond, et al.
Publicado: (2012)

Familial longevity is characterized by high circadian rhythmicity of serum cholesterol in healthy elderly individuals
por: van den Berg, Rosa, et al.
Publicado: (2016)

Improved selection of participants in genetic longevity studies: family scores revisited
por: Rodríguez-Girondo, Mar, et al.
Publicado: (2021)

Lifestyle‐Intervention‐Induced Reduction of Abdominal Fat Is Reflected by a Decreased Circulating Glycerol Level and an Increased HDL Diameter
por: Beekman, Marian, et al.
Publicado: (2020)

Lipidomics of familial longevity
por: Gonzalez-Covarrubias, Vanessa, et al.
Publicado: (2013)

Longevity Relatives Count score identifies heritable longevity carriers and suggests case improvement in genetic studies
por: van den Berg, Niels, et al.
Publicado: (2020)

Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study
por: van der Spoel, Evie, et al.
Publicado: (2015)

Familial Longevity Is Not Associated with Major Differences in the Hypothalamic–Pituitary–Gonadal Axis in Healthy Middle-Aged Men
por: van der Spoel, Evie, et al.
Publicado: (2016)

Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways
por: Deelen, Joris, et al.
Publicado: (2011)

The effect of standardized food intake on the association between BMI and (1)H-NMR metabolites
por: Schutte, Bianca A. M., et al.
Publicado: (2016)

Differential insulin sensitivity of NMR-based metabolomic measures in a two-step hyperinsulinemic euglycemic clamp study
por: Wang, Wenyi, et al.
Publicado: (2021)

Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R
por: Passtoors, Willemijn M., et al.
Publicado: (2012)

Association of Liver Enzymes and Computed Tomography Markers of Liver Steatosis with Familial Longevity
por: Sala, Michiel, et al.
Publicado: (2014)

Genomics of human longevity
por: Slagboom, P. E., et al.
Publicado: (2011)

Correction: Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R
por: Passtoors, Willemijn M., et al.
Publicado: (2012)

Lipoprotein Particle Profiles Mark Familial and Sporadic Human Longevity
por: Heijmans, Bastiaan T, et al.
Publicado: (2006)

Secondary phenotype analysis in ascertained family designs: application to the Leiden longevity study
por: Tissier, Renaud, et al.
Publicado: (2017)

High Adiposity Is Associated With Higher Nocturnal and Diurnal Glycaemia, but Not With Glycemic Variability in Older Individuals Without Diabetes
por: Noordam, Raymond, et al.
Publicado: (2018)

Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age
por: Akintola, Abimbola A., et al.
Publicado: (2015)

Relative validity of the food frequency questionnaire used to assess dietary intake in the Leiden Longevity Study
por: Streppel, Martinette T, et al.
Publicado: (2013)

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
por: Deelen, Joris, et al.
Publicado: (2011)

Handgrip strength at midlife and familial longevity: The Leiden Longevity Study
por: Ling, Carolina H. Y., et al.
Publicado: (2011)

Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity
por: van der Spoel, Evie, et al.
Publicado: (2016)

Thyroid status and mortality in nonagenarians from long-lived families and the general population
por: van Vliet, Nicolien A., et al.
Publicado: (2017)

Longevity Around the Turn of the 20th Century: Life-Long Sustained Survival Advantage for Parents of Today’s Nonagenarians
por: van den Berg, Niels, et al.
Publicado: (2018)

The association between continuous ambulatory heart rate, heart rate variability, and 24-h rhythms of heart rate with familial longevity and aging
por: Wiersema, Janneke M., et al.
Publicado: (2022)

High Liver Enzyme Concentrations are Associated with Higher Glycemia, but not with Glycemic Variability, in Individuals without Diabetes Mellitus
por: Noordam, Raymond, et al.
Publicado: (2017)

ApoE Plasma Levels and Risk of Cardiovascular Mortality in Old Age
por: Mooijaart, Simon P, et al.
Publicado: (2006)

IL7R gene expression network associates with human healthy ageing
por: Passtoors, Willemijn M., et al.
Publicado: (2015)

Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait
por: van den Berg, Niels, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_vskps10lilhfs3sgegprq53eka