IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization

Atopic dermatitis (AD) is a Th2-dominated inflammatory skin disease characterized by epidermal thickening. Serum levels of IL-22, a cytokine known to induce keratinocyte proliferation, are elevated in AD, and Th22 cells infiltrate AD skin lesions. We show that application of antigen to mouse skin su...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoon, Juhan, Leyva-Castillo, Juan Manuel, Wang, Guoxing, Galand, Claire, Oyoshi, Michiko K., Kumar, Lalit, Hoff, Sabine, He, Rui, Chervonsky, Alexander, Oppenheim, Joost J., Kuchroo, Vijay K., van den Brink, Marcel R.M., Malefyt, Rene De Waal, Tessier, Philippe A., Fuhlbrigge, Robert, Rosenstiel, Philip, Terhorst, Cox, Murphy, George, Geha, Raif S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032726/
https://www.ncbi.nlm.nih.gov/pubmed/27551155
http://dx.doi.org/10.1084/jem.20150376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032726/
https://www.ncbi.nlm.nih.gov/pubmed/27551155
http://dx.doi.org/10.1084/jem.20150376

Ejemplares similares