Non‐clinical safety evaluation of repeated intramuscular administration of the AS15 immunostimulant combined with various antigens in rabbits and cynomolgus monkeys

Combination of tumor antigens with immunostimulants is a promising approach in cancer immunotherapy. We assessed animal model toxicity of AS15 combined with various tumor antigens: WT1 (rabbits), or p501, dHER2 and recPRAME (cynomolgus monkeys), administered in seven or 20 dose regimens versus a sal...

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Detalles Bibliográficos
Autores principales: Garçon, N., Silvano, J., Kuper, C. F., Baudson, N., Gérard, C., Forster, R., Segal, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033012/
https://www.ncbi.nlm.nih.gov/pubmed/26032931
http://dx.doi.org/10.1002/jat.3167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033012/
https://www.ncbi.nlm.nih.gov/pubmed/26032931
http://dx.doi.org/10.1002/jat.3167

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