Polyglutamine Tract Expansion Increases S-Nitrosylation of Huntingtin and Ataxin-1

Expansion of the polyglutamine (polyQ) tract in the huntingtin (Htt) protein causes Huntington’s disease (HD), a fatal inherited movement disorder linked to neurodegeneration in the striatum and cortex. S-nitrosylation and S-acylation of cysteine residues regulate many functions of cytosolic protein...

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Detalles Bibliográficos
Autores principales: Ni, Chun-Lun, Seth, Divya, Fonseca, Fabio Vasconcelos, Wang, Liwen, Xiao, Tsan Sam, Gruber, Phillip, Sy, Man-Sun, Stamler, Jonathan S., Tartakoff, Alan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033456/
https://www.ncbi.nlm.nih.gov/pubmed/27658206
http://dx.doi.org/10.1371/journal.pone.0163359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033456/
https://www.ncbi.nlm.nih.gov/pubmed/27658206
http://dx.doi.org/10.1371/journal.pone.0163359

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