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Polyglutamine Tract Expansion Increases S-Nitrosylation of Huntingtin and Ataxin-1

Expansion of the polyglutamine (polyQ) tract in the huntingtin (Htt) protein causes Huntington’s disease (HD), a fatal inherited movement disorder linked to neurodegeneration in the striatum and cortex. S-nitrosylation and S-acylation of cysteine residues regulate many functions of cytosolic protein...

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Detalles Bibliográficos
Autores principales:	Ni, Chun-Lun, Seth, Divya, Fonseca, Fabio Vasconcelos, Wang, Liwen, Xiao, Tsan Sam, Gruber, Phillip, Sy, Man-Sun, Stamler, Jonathan S., Tartakoff, Alan M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033456/ https://www.ncbi.nlm.nih.gov/pubmed/27658206 http://dx.doi.org/10.1371/journal.pone.0163359

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