Disease Phenotypes in a Mouse Model of RNA Toxicity Are Independent of Protein Kinase Cα and Protein Kinase Cβ

Myotonic dystrophy type 1(DM1) is the prototype for diseases caused by RNA toxicity. RNAs from the mutant allele contain an expanded (CUG)(n) tract within the 3' untranslated region of the dystrophia myotonica protein kinase (DMPK) gene. The toxic RNAs affect the function of RNA binding protein...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Yun K., Yadava, Ramesh S., Mandal, Mahua, Mahadevan, Karunasai, Yu, Qing, Leitges, Michael, Mahadevan, Mani S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033491/
https://www.ncbi.nlm.nih.gov/pubmed/27657532
http://dx.doi.org/10.1371/journal.pone.0163325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033491/
https://www.ncbi.nlm.nih.gov/pubmed/27657532
http://dx.doi.org/10.1371/journal.pone.0163325

Ejemplares similares