N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A

Botulinum neurotoxin serotype A1 (BoNT/A1) is one of the most dangerous potential bioterrorism agents, and exerts its action by invading motoneurons. It is also a licensed drug widely used for medical and cosmetic applications. Here we report a 2.0 Å resolution crystal structure of BoNT/A1 receptor-...

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Detalles Bibliográficos
Autores principales: Yao, Guorui, Zhang, Sicai, Mahrhold, Stefan, Lam, Kwok-ho, Stern, Daniel, Bagramyan, Karine, Perry, Kay, Kalkum, Markus, Rummel, Andreas, Dong, Min, Jin, Rongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033645/
https://www.ncbi.nlm.nih.gov/pubmed/27294781
http://dx.doi.org/10.1038/nsmb.3245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033645/
https://www.ncbi.nlm.nih.gov/pubmed/27294781
http://dx.doi.org/10.1038/nsmb.3245

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