Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases

The hypoxia-inducible factor (HIF) system orchestrates cellular responses to hypoxia in animals. HIF is an α/β-heterodimeric transcription factor that regulates the expression of hundreds of genes in a tissue context-dependent manner. The major hypoxia-sensing component of the HIF system involves ox...

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Detalles Bibliográficos
Autores principales: Chan, Mun Chiang, Ilott, Nicholas E., Schödel, Johannes, Sims, David, Tumber, Anthony, Lippl, Kerstin, Mole, David R., Pugh, Christopher W., Ratcliffe, Peter J., Ponting, Chris P., Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Gene Regulation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034057/
https://www.ncbi.nlm.nih.gov/pubmed/27502280
http://dx.doi.org/10.1074/jbc.M116.749291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034057/
https://www.ncbi.nlm.nih.gov/pubmed/27502280
http://dx.doi.org/10.1074/jbc.M116.749291

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