Decreased IL7Rα and TdT expression underlie the skewed immunoglobulin repertoire of human B-cell precursors from fetal origin

Newborns are unable to mount antibody responses towards certain antigens. This has been related to the restricted repertoire of immunoglobulin (Ig) genes of their B cells. The mechanisms underlying the restricted fetal Ig gene repertoire are currently unresolved. We here addressed this with detailed...

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Detalles Bibliográficos
Autores principales: Rother, Magdalena B., Jensen, Kristin, van der Burg, Mirjam, van de Bovenkamp, Fleur S., Kroek, Roel, van IJcken, Wilfred F. J., van der Velden, Vincent H. J., Cupedo, Tom, Olstad, Ole K., van Dongen, Jacques J. M., van Zelm, Menno C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034271/
https://www.ncbi.nlm.nih.gov/pubmed/27658954
http://dx.doi.org/10.1038/srep33924

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034271/
https://www.ncbi.nlm.nih.gov/pubmed/27658954
http://dx.doi.org/10.1038/srep33924

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