Solid-State NMR Structure of a Pathogenic Fibril of Full-Length Human α-Synuclein

Misfolded α-synuclein amyloid fibrils are the principal components of Lewy bodies and neurites, hallmarks of Parkinson’s disease (PD). Here we present a high-resolution structure of an α-synuclein fibril, in a form that induces robust pathology in primary neuronal culture, determined by solid-state...

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Detalles Bibliográficos
Autores principales: Tuttle, Marcus D., Comellas, Gemma, Nieuwkoop, Andrew J., Covell, Dustin J., Berthold, Deborah A., Kloepper, Kathryn D., Courtney, Joseph M., Kim, Jae K., Barclay, Alexander M., Kendall, Amy, Wan, William, Stubbs, Gerald, Schwieters, Charles D., Lee, Virginia M. Y., George, Julia M., Rienstra, Chad M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034296/
https://www.ncbi.nlm.nih.gov/pubmed/27018801
http://dx.doi.org/10.1038/nsmb.3194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034296/
https://www.ncbi.nlm.nih.gov/pubmed/27018801
http://dx.doi.org/10.1038/nsmb.3194

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