Cargando…

Solid-State NMR Structure of a Pathogenic Fibril of Full-Length Human α-Synuclein

Misfolded α-synuclein amyloid fibrils are the principal components of Lewy bodies and neurites, hallmarks of Parkinson’s disease (PD). Here we present a high-resolution structure of an α-synuclein fibril, in a form that induces robust pathology in primary neuronal culture, determined by solid-state...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tuttle, Marcus D., Comellas, Gemma, Nieuwkoop, Andrew J., Covell, Dustin J., Berthold, Deborah A., Kloepper, Kathryn D., Courtney, Joseph M., Kim, Jae K., Barclay, Alexander M., Kendall, Amy, Wan, William, Stubbs, Gerald, Schwieters, Charles D., Lee, Virginia M. Y., George, Julia M., Rienstra, Chad M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034296/ https://www.ncbi.nlm.nih.gov/pubmed/27018801 http://dx.doi.org/10.1038/nsmb.3194

Ejemplares similares

Site-Specific Perturbations of Alpha-Synuclein Fibril Structure by the Parkinson's Disease Associated Mutations A53T and E46K
por: Lemkau, Luisel R., et al.
Publicado: (2013)

13C and 15N Resonance Assignments of Alpha Synuclein Fibrils Amplified from Lewy Body Dementia Tissue
por: Barclay, Alexander M., et al.
Publicado: (2023)

Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue
por: Dhavale, Dhruva D., et al.
Publicado: (2023)

High-Resolution NMR Studies of Human Tissue Factor
por: Nuzzio, Kristin M., et al.
Publicado: (2016)

Conjoined Use of EM and NMR in RNA Structure Refinement
por: Gong, Zhou, et al.
Publicado: (2015)

Amphotericin forms an extramembranous and fungicidal sterol sponge
por: Anderson, Thomas M., et al.
Publicado: (2014)

Site-Specific Internal Motions in GB1 Protein Microcrystals Revealed by 3D (2)H–(13)C–(13)C Solid-State NMR Spectroscopy
por: Shi, Xiangyan, et al.
Publicado: (2016)

Cellular Milieu Imparts Distinct Pathological α-Synuclein Strains in α-Synucleinopathies
por: Peng, Chao, et al.
Publicado: (2018)

Using an NMR metabolomics approach to investigate the pathogenicity of amyloid-beta and alpha-synuclein
por: Phelan, M. M., et al.
Publicado: (2017)

Automated protein resonance assignments of magic angle spinning solid-state NMR spectra of β1 immunoglobulin binding domain of protein G (GB1)
por: Moseley, Hunter N. B., et al.
Publicado: (2010)

Protein fold determined by paramagnetic magic-angle spinning solid-state NMR spectroscopy
por: Sengupta, Ishita, et al.
Publicado: (2012)

Atomic-resolution structure of HIV-1 capsid tubes by magic-angle spinning NMR
por: Lu, Manman, et al.
Publicado: (2020)

Interaction of the bacterial division regulator MinE with lipid bicelles studied by NMR spectroscopy
por: Cai, Mengli, et al.
Publicado: (2023)

Salient Features of Monomeric Alpha-Synuclein Revealed by NMR Spectroscopy
por: Kim, Do-Hyoung, et al.
Publicado: (2020)

Metal interactions of α-synuclein probed by NMR amide-proton exchange
por: Gonzalez-Garcia, Mario, et al.
Publicado: (2023)

In-Cell NMR Characterization of the Secondary Structure Populations of a Disordered Conformation of α-Synuclein within E. coli Cells
por: Waudby, Christopher A., et al.
Publicado: (2013)

Time-resolved DEER EPR and solid-state NMR afford kinetic and structural elucidation of substrate binding to Ca(2+)-ligated calmodulin
por: Schmidt, Thomas, et al.
Publicado: (2022)

NMR Exchange Format: a unified and open standard for representation of NMR restraint data
por: Gutmanas, Aleksandras, et al.
Publicado: (2015)

Transmission of alpha-synuclein in Parkinson’s disease
por: Lee, Virginia M-Y
Publicado: (2013)

Identification and Quantification of Oxidation Products in Full-Length Biotherapeutic Antibodies by NMR Spectroscopy
por: Hinterholzer, Arthur, et al.
Publicado: (2020)

Differential Phospholipid Binding of α-Synuclein Variants Implicated in Parkinson’s Disease Revealed by Solution NMR Spectroscopy
por: Bodner, Christina R., et al.
Publicado: (2009)

Isolation, purification, and full NMR assignments of cyclopamine from Veratrum californicum
por: Oatis, John E, et al.
Publicado: (2008)

Impairment of Mitochondria in Adult Mouse Brain Overexpressing Predominantly Full-Length, N-Terminally Acetylated Human α-Synuclein
por: Sarafian, Theodore A., et al.
Publicado: (2013)

Mechanistic Insight into the Relationship between N-Terminal Acetylation of α-Synuclein and Fibril Formation Rates by NMR and Fluorescence
por: Kang, Lijuan, et al.
Publicado: (2013)

Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel
por: Li, Binsen, et al.
Publicado: (2018)

The synucleins
por: George, Julia M
Publicado: (2002)

Unlike Twins: An NMR Comparison of Two α-Synuclein Polymorphs Featuring Different Toxicity
por: Gath, Julia, et al.
Publicado: (2014)

Interactions between S100A9 and Alpha-Synuclein: Insight from NMR Spectroscopy
por: Toleikis, Zigmantas, et al.
Publicado: (2022)

Growth studies of subcutaneous rat tumours: comparison of 31P-NMR spectroscopy, acid extracts and histology.
por: Stubbs, M., et al.
Publicado: (1989)

Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy
por: Guerrero-Ferreira, Ricardo, et al.
Publicado: (2019)

REMD Simulations of Full-Length Alpha-Synuclein Together with Ligands Reveal Binding Region and Effect on Amyloid Conversion
por: Semenyuk, Pavel I.
Publicado: (2022)

α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
por: Tran, Hien T., et al.
Publicado: (2014)

GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson’s Disease
por: Schneider, Jay S., et al.
Publicado: (2019)

Ligand-modulated folding of the full-length adenine riboswitch probed by NMR and single-molecule FRET spectroscopy
por: Warhaut, Sven, et al.
Publicado: (2017)

Site-Specific Interaction between α-Synuclein and Membranes Probed by NMR-Observed Methionine Oxidation Rates
por: Maltsev, Alexander S., et al.
Publicado: (2013)

DNP-Enhanced MAS NMR: A Tool to Snapshot Conformational Ensembles of α-Synuclein in Different States
por: Uluca, Boran, et al.
Publicado: (2018)

Comparison of the 3D structures of mouse and human α-synuclein fibrils by solid-state NMR and STEM()
por: Hwang, Songhwan, et al.
Publicado: (2019)

Membrane Interactions of α-Synuclein Revealed by Multiscale Molecular Dynamics Simulations, Markov State Models, and NMR
por: Amos, Sarah-Beth T. A., et al.
Publicado: (2021)

Triphala inhibits alpha-synuclein fibrillization and their interaction study by NMR provides insights into the self-association of the protein
por: Bopardikar, Mandar, et al.
Publicado: (2019)

Spatially resolved DNP-assisted NMR illuminates the conformational ensemble of α-synuclein in intact viable cells
por: Kragelj, Jaka, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_9mq800eevplh7sl6hhbsee3q6i