SENP1 Is a Crucial Regulator for Cell Senescence through DeSUMOylation of Bmi1

Cell senescence can limit proliferative potential and prevent tumorigenesis. Bmi1 is a key regulator in cell senescence by suppressing the Ink4a/Arf locus. However, how to regulate Bmi1 activity in cell senescence is largely unknown. Here, we show that SENP1 plays an important role in cell senescenc...

Descripción completa

Detalles Bibliográficos
Autores principales: Xia, Nansong, Cai, Juan, Wang, Feifei, Dong, Baijun, Liu, Song, Chen, Fengling, Cheng, Jinke, Zuo, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034316/
https://www.ncbi.nlm.nih.gov/pubmed/27659494
http://dx.doi.org/10.1038/srep34099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034316/
https://www.ncbi.nlm.nih.gov/pubmed/27659494
http://dx.doi.org/10.1038/srep34099

Ejemplares similares