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SENP1 Is a Crucial Regulator for Cell Senescence through DeSUMOylation of Bmi1

Cell senescence can limit proliferative potential and prevent tumorigenesis. Bmi1 is a key regulator in cell senescence by suppressing the Ink4a/Arf locus. However, how to regulate Bmi1 activity in cell senescence is largely unknown. Here, we show that SENP1 plays an important role in cell senescenc...

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Detalles Bibliográficos
Autores principales:	Xia, Nansong, Cai, Juan, Wang, Feifei, Dong, Baijun, Liu, Song, Chen, Fengling, Cheng, Jinke, Zuo, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034316/ https://www.ncbi.nlm.nih.gov/pubmed/27659494 http://dx.doi.org/10.1038/srep34099

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