Depletion of γ-glutamylcyclotransferase inhibits breast cancer cell growth via cellular senescence induction mediated by CDK inhibitor upregulation

BACKGROUND: Chromosome 7 open reading frame 24 (C7orf24) was originally identified as a highly expressed protein in various types of cancer, and later shown to be a γ-glutamylcyclotransferase (GGCT). GGCT depletion in cancer cells has anti-proliferative effects in vitro and in vivo, and it is theref...

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Detalles Bibliográficos
Autores principales: Matsumura, Kengo, Nakata, Susumu, Taniguchi, Keiko, Ii, Hiromi, Ashihara, Eishi, Kageyama, Susumu, Kawauchi, Akihiro, Yoshiki, Tatsuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034417/
https://www.ncbi.nlm.nih.gov/pubmed/27658708
http://dx.doi.org/10.1186/s12885-016-2779-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034417/
https://www.ncbi.nlm.nih.gov/pubmed/27658708
http://dx.doi.org/10.1186/s12885-016-2779-y

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