Is radiographic progression in modern rheumatoid arthritis trials still a robust outcome? Experience from tofacitinib clinical trials

BACKGROUND: The detection of statistically significant reductions in radiographic progression during clinical studies in patients with rheumatoid arthritis (RA) has become increasingly difficult over the past decade due to early-escape study designs and declining rates of progression in control-grou...

Descripción completa

Detalles Bibliográficos
Autores principales: Landewé, Robert B. M., Connell, Carol A., Bradley, John D., Wilkinson, Bethanie, Gruben, David, Strengholt, Sander, van der Heijde, Désirée
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034418/
https://www.ncbi.nlm.nih.gov/pubmed/27663201
http://dx.doi.org/10.1186/s13075-016-1106-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034418/
https://www.ncbi.nlm.nih.gov/pubmed/27663201
http://dx.doi.org/10.1186/s13075-016-1106-y

Ejemplares similares