Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD

BACKGROUND: Peptidyl-prolyl isomerases (PPIases) catalyze cis/trans isomerization of peptidyl-prolyl bonds, which is often rate-limiting for protein folding. SlyD is a two-domain enzyme containing both a PPIase FK506-binding protein (FKBP) domain and an insert-in-flap (IF) chaperone domain. To date,...

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Detalles Bibliográficos
Autores principales: Quistgaard, Esben M., Weininger, Ulrich, Ural-Blimke, Yonca, Modig, Kristofer, Nordlund, Pär, Akke, Mikael, Löw, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034536/
https://www.ncbi.nlm.nih.gov/pubmed/27664121
http://dx.doi.org/10.1186/s12915-016-0300-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034536/
https://www.ncbi.nlm.nih.gov/pubmed/27664121
http://dx.doi.org/10.1186/s12915-016-0300-3

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