Stereoselective Metabolism of Bupropion to OH-bupropion, Threohydrobupropion, Erythrohydrobupropion, and 4′-OH-bupropion in vitro

Bupropion is a widely used antidepressant, smoking cessation aid, and weight-loss therapy. It is administered as a racemic mixture, but the pharmacokinetics and activity of bupropion are stereoselective. The activity and side effects of bupropion are attributed to bupropion and its metabolites S,S-...

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Detalles Bibliográficos
Autores principales: Sager, Jennifer E., Price, Lauren S. L., Isoherranen, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034696/
https://www.ncbi.nlm.nih.gov/pubmed/27495292
http://dx.doi.org/10.1124/dmd.116.072363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034696/
https://www.ncbi.nlm.nih.gov/pubmed/27495292
http://dx.doi.org/10.1124/dmd.116.072363

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