Cargando…

Abundance of Hepatic Transporters in Caucasians: A Meta-Analysis

This study aimed to derive quantitative abundance values for key hepatic transporters suitable for in vitro–in vivo extrapolation within a physiologically based pharmacokinetic modeling framework. A meta-analysis was performed whereby data on abundance measurements, sample preparation methods, and d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Burt, Howard J., Riedmaier, Arian Emami, Harwood, Matthew D., Crewe, H. Kim, Gill, Katherine L., Neuhoff, Sibylle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034697/ https://www.ncbi.nlm.nih.gov/pubmed/27493152 http://dx.doi.org/10.1124/dmd.116.071183

Ejemplares similares

More Power to OATP1B1: An Evaluation of Sample Size in Pharmacogenetic Studies Using a Rosuvastatin PBPK Model for Intestinal, Hepatic, and Renal Transporter‐Mediated Clearances
por: Emami Riedmaier, Ariane, et al.
Publicado: (2016)

Physiologically‐Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug–Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations
por: Taskar, Kunal S., et al.
Publicado: (2019)

Mass spectrometry‐based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin
por: Al‐Majdoub, Zubida M., et al.
Publicado: (2020)

Prediction of CYP‐mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator
por: Kilford, Peter J., et al.
Publicado: (2022)

Protein Abundance of Drug Transporters in Human Hepatitis C Livers
por: Droździk, Marek, et al.
Publicado: (2022)

Performance Verification of CYP2C19 Enzyme Abundance Polymorphism Settings within the Simcyp Simulator v21
por: Sychterz, Caroline, et al.
Publicado: (2022)

Transporter Regulation in Critical Protective Barriers: Focus on Brain and Placenta
por: Taggi, Valerio, et al.
Publicado: (2022)

Finding abundance regulators
por: Ozguc, Olivia, et al.
Publicado: (2022)

Liquid Biopsy Enables Quantification of the Abundance and Interindividual Variability of Hepatic Enzymes and Transporters
por: Achour, Brahim, et al.
Publicado: (2020)

The sero-epidemiology of human papillomavirus among Caucasian transplant recipients in the UK
por: Casabonne, Delphine, et al.
Publicado: (2009)

Regulatory utility of physiologically based pharmacokinetic modeling for assessing food impact in bioequivalence studies: A workshop summary report
por: Al Shoyaib, Abdullah, et al.
Publicado: (2023)

Craniofacial characteristics of Caucasian and Afro-Caucasian Brazilian subjects with normal occlusion
por: JANSON, Guilherme, et al.
Publicado: (2011)

Temperature and iron abundance variation of the gas in the Perseus cluster
por: Arnaud, K A, et al.
Publicado: (1994)

PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants
por: Emoto, Chie, et al.
Publicado: (2018)

Clinical features of alcoholic hepatitis in latinos and caucasians: A single center experience
por: Pinon-Gutierrez, Rogelio, et al.
Publicado: (2017)

The Caucasian chalk circle
por: Brecht, Bertolt, 1898-1956
Publicado: (1966)

Bioactive oat β-glucan reduces LDL cholesterol in Caucasians and non-Caucasians
por: Wolever, Thomas MS, et al.
Publicado: (2011)

Changes in hematologic indices in caucasian and non-caucasian pregnant women in the United States
por: Harm, Sarah K., et al.
Publicado: (2012)

Survival analysis in Caucasian pulmonary adenocarcinoma patients based on differential targets between Caucasian and Asian population
por: Zhu, Zheng, et al.
Publicado: (2018)

Comparison of cephalometric norms of caucasians and non-caucasians: A forensic aid in ethnic determination
por: Kavitha, L, et al.
Publicado: (2012)

Sporadic Fusobacterium Bacteremia as an Atypical Cause of Acute Hepatitis in a Young Caucasian Woman
por: Ahmed, Nishat, et al.
Publicado: (2020)

Genome-wide meta-analysis identified novel variant associated with hallux valgus in Caucasians
por: Arbeeva, Liubov, et al.
Publicado: (2020)

B-lymphocyte alloantigens in Caucasians
Publicado: (1976)

Assessing Potential Drug–Drug Interactions Between Dabigatran Etexilate and a P‐Glycoprotein Inhibitor in Renal Impairment Populations Using Physiologically Based Pharmacokinetic Modeling
por: Doki, Kosuke, et al.
Publicado: (2019)

Association of Serotonin Transporter (SERT) Polymorphisms with Opioid Dependence and Dimensional Aspects of Cocaine Use in a Caucasian Cohort of Opioid Users
por: Yuferov, Vadim, et al.
Publicado: (2021)

Predicting Total, Abdominal, Visceral and Hepatic Adiposity with Circulating Biomarkers in Caucasian and Japanese American Women
por: Lim, Unhee, et al.
Publicado: (2012)

Association of the HLA locus and TNF with type I autoimmune hepatitis susceptibility in New Zealand Caucasians
por: Ngu, Jing H, et al.
Publicado: (2013)

Associations between ghrelin and ghrelin receptor polymorphisms and cancer in Caucasian populations: a meta-analysis
por: Pabalan, Noel A, et al.
Publicado: (2014)

Regulation of Drug Transport Proteins—From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium
por: Brouwer, Kim L.R., et al.
Publicado: (2022)

Interlaboratory Variability in the Madin–Darby Canine Kidney Cell Proteome
por: Harwood, Matthew D., et al.
Publicado: (2023)

Phenotype-Genotype analysis of caucasian patients with high risk of osteoarthritis
por: Wang, Yanfei, et al.
Publicado: (2022)

STARD4 abundance regulates sterol transport and sensing
por: Mesmin, Bruno, et al.
Publicado: (2011)

Absence of lateral palpebral raphe in Caucasians
por: Goold, Lucy, et al.
Publicado: (2009)

Oriental Cholangiohepatitis in a Caucasian male
por: Suarez, Laura Suzanne K, et al.
Publicado: (2021)

Moyamoya Disease and Syndrome in Caucasian Patients
por: Neves, Nuno, et al.
Publicado: (2023)

Predictive performance of newer Asian hepatocellular carcinoma risk scores in treated Caucasians with chronic hepatitis B
por: Papatheodoridis, George V., et al.
Publicado: (2021)

Genetic analysis of the GLUT10 glucose transporter (SLC2A10) polymorphisms in Caucasian American type 2 diabetes
por: Bento, Jennifer L, et al.
Publicado: (2005)

Comparison of Anthropometric Data Between Asian and Caucasian Patients With Obstructive Sleep Apnea: A Meta-Analysis
por: Cho, Jae Hoon, et al.
Publicado: (2016)

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug–Drug Interactions
por: Antonescu, Irina E., et al.
Publicado: (2020)

Comparison of Placebo Effect between Asian and Caucasian Type 2 Diabetic Patients: A Meta-Analysis
por: Guo, Wei, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_j7por4drumnophrkj7c002n2gt