The potent, indirect adenosine monophosphate-activated protein kinase activator R419 attenuates mitogen-activated protein kinase signaling, inhibits nociceptor excitability, and reduces pain hypersensitivity in mice

There is a great need for new therapeutics for the treatment of pain. A possible avenue to development of such therapeutics is to interfere with signaling pathways engaged in peripheral nociceptors that cause these neurons to become hyperexcitable. There is strong evidence that mitogen-activated pro...

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Detalles Bibliográficos
Autores principales: Mejia, Galo L., Asiedu, Marina N., Hitoshi, Yasumichi, Dussor, Gregory, Price, Theodore J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2016
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034875/
https://www.ncbi.nlm.nih.gov/pubmed/27672681
http://dx.doi.org/10.1097/PR9.0000000000000562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034875/
https://www.ncbi.nlm.nih.gov/pubmed/27672681
http://dx.doi.org/10.1097/PR9.0000000000000562

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