Reduction of apoptosis and preservation of mitochondrial integrity under ischemia/reperfusion injury is mediated by estrogen receptor β

BACKGROUND: Estrogen improves cardiac recovery after ischemia/reperfusion (I/R) by yet incompletely understood mechanisms. Mitochondria play a crucial role in I/R injury through cytochrome c-dependent apoptosis activation. We tested the hypothesis that 17β-estradiol (E2) as well as a specific ERβ ag...

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Detalles Bibliográficos
Autores principales: Schubert, Carola, Raparelli, Valeria, Westphal, Christina, Dworatzek, Elke, Petrov, George, Kararigas, Georgios, Regitz-Zagrosek, Vera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035458/
https://www.ncbi.nlm.nih.gov/pubmed/27688871
http://dx.doi.org/10.1186/s13293-016-0104-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035458/
https://www.ncbi.nlm.nih.gov/pubmed/27688871
http://dx.doi.org/10.1186/s13293-016-0104-8

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