CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and l-type Ca(2+) channels upstream of p38 MAPK

BACKGROUND: The chemokine receptor CXCR4 (CD184) and its natural ligand CXCL12 contribute to many physiological processes, including decisions about cell death and survival in the central nervous system. In addition, CXCR4 is a co-receptor for human immunodeficiency virus (HIV)-1 and mediates the ne...

Descripción completa

Detalles Bibliográficos
Autores principales: Sanchez, Ana B., Medders, Kathryn E., Maung, Ricky, Sánchez-Pavón, Paloma, Ojeda-Juárez, Daniel, Kaul, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035480/
https://www.ncbi.nlm.nih.gov/pubmed/27664068
http://dx.doi.org/10.1186/s12974-016-0724-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035480/
https://www.ncbi.nlm.nih.gov/pubmed/27664068
http://dx.doi.org/10.1186/s12974-016-0724-2

Ejemplares similares