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4-1BB agonism: adding the accelerator to cancer immunotherapy

The success of checkpoint inhibitors has validated immunomodulatory agents as a valuable class of anticancer therapeutics. A promising co-stimulatory immunologic target is 4-1BB, or CD137, a member of the tumor necrosis factor receptor superfamily. Ligation of 4-1BB induces an activating signal in C...

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Detalles Bibliográficos
Autores principales: Chester, Cariad, Ambulkar, Siddhant, Kohrt, Holbrook E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035667/
https://www.ncbi.nlm.nih.gov/pubmed/27034234
http://dx.doi.org/10.1007/s00262-016-1829-2