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Why Is there a Limit to the Changes in Myofilament Ca(2+)-Sensitivity Associated with Myopathy Causing Mutations?

Mutations in striated muscle contractile proteins have been found to be the cause of a number of inherited muscle diseases; in most cases the mechanism proposed for causing the disease is derangement of the thin filament-based Ca(2+)-regulatory system of the muscle. When considering the results of e...

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Detalles Bibliográficos
Autor principal: Marston, Steven B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035734/
https://www.ncbi.nlm.nih.gov/pubmed/27725803
http://dx.doi.org/10.3389/fphys.2016.00415