TDP-43 aggregation mirrors TDP-43 knockdown, affecting the expression levels of a common set of proteins

TDP-43 protein plays an important role in regulating transcriptional repression, RNA metabolism, and splicing. Typically it shuttles between the nucleus and the cytoplasm to perform its functions, while abnormal cytoplasmic aggregation of TDP-43 has been associated with neurodegenerative diseases am...

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Detalles Bibliográficos
Autores principales: Prpar Mihevc, S., Baralle, Marco, Buratti, Emanuele, Rogelj, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036055/
https://www.ncbi.nlm.nih.gov/pubmed/27665936
http://dx.doi.org/10.1038/srep33996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036055/
https://www.ncbi.nlm.nih.gov/pubmed/27665936
http://dx.doi.org/10.1038/srep33996

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