Etoposide induced cytotoxicity mediated by ROS and ERK in human kidney proximal tubule cells

Etoposide (ETO) is a commonly used chemotherapeutic drug that inhibits topoisomerase II activity, thereby leading to genotoxicity and cytotoxicity. However, ETO has limited application due to its side effects on normal organs, especially the kidney. Here, we report the mechanism of ETO-induced cytot...

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Detalles Bibliográficos
Autores principales: Shin, Hyeon-Jun, Kwon, Hyuk-Kwon, Lee, Jae-Hyeok, Anwar, Muhammad Ayaz, Choi, Sangdun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036097/
https://www.ncbi.nlm.nih.gov/pubmed/27666530
http://dx.doi.org/10.1038/srep34064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036097/
https://www.ncbi.nlm.nih.gov/pubmed/27666530
http://dx.doi.org/10.1038/srep34064

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