Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities

Cyclophilins are peptidyl-prolyl cis/trans isomerases (PPIase) that catalyse the interconversion of the peptide bond at proline residues. Several cyclophilins play a pivotal role in the life cycle of a number of viruses. The existing cyclophilin inhibitors, all derived from cyclosporine A or sanglif...

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Detalles Bibliográficos
Autores principales: Ahmed-Belkacem, Abdelhakim, Colliandre, Lionel, Ahnou, Nazim, Nevers, Quentin, Gelin, Muriel, Bessin, Yannick, Brillet, Rozenn, Cala, Olivier, Douguet, Dominique, Bourguet, William, Krimm, Isabelle, Pawlotsky, Jean-Michel, Guichou, Jean- François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036131/
https://www.ncbi.nlm.nih.gov/pubmed/27652979
http://dx.doi.org/10.1038/ncomms12777

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036131/
https://www.ncbi.nlm.nih.gov/pubmed/27652979
http://dx.doi.org/10.1038/ncomms12777

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