HIV-1 Tat Inhibits Autotaxin Lysophospholipase D Activity and Modulates Oligodendrocyte Differentiation

White matter injury has been frequently reported in HIV(+) patients. Previous studies showed that HIV-1 Tat (transactivator of transcription), a viral protein that is produced and secreted by HIV-infected cells, is toxic to young, immature oligodendrocytes (OLGs). Adding Tat to the culture medium re...

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Detalles Bibliográficos
Autores principales: Wheeler, Natalie A., Fuss, Babette, Knapp, Pamela E., Zou, ShiPing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036141/
https://www.ncbi.nlm.nih.gov/pubmed/27659560
http://dx.doi.org/10.1177/1759091416669618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036141/
https://www.ncbi.nlm.nih.gov/pubmed/27659560
http://dx.doi.org/10.1177/1759091416669618

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