Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome

Endothelial dysfunction is a hallmark of systemic inflammatory response underlying multiple organ failure. Here we report a novel function of DHHC-containing palmitoyl acyltransferases (PATs) in mediating endothelial inflammation. Pharmacological inhibition of PATs attenuates barrier leakage and leu...

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Detalles Bibliográficos
Autores principales: Beard, Richard S., Yang, Xiaoyuan, Meegan, Jamie E., Overstreet, Jonathan W., Yang, Clement G.Y., Elliott, John A., Reynolds, Jason J., Cha, Byeong J., Pivetti, Christopher D., Mitchell, David A., Wu, Mack H., Deschenes, Robert J., Yuan, Sarah Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036164/
https://www.ncbi.nlm.nih.gov/pubmed/27653213
http://dx.doi.org/10.1038/ncomms12823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036164/
https://www.ncbi.nlm.nih.gov/pubmed/27653213
http://dx.doi.org/10.1038/ncomms12823

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