G9a inhibits MEF2C activity to control sarcomere assembly

In this study, we demonstrate that the lysine methyltransferase G9a inhibits sarcomere organization through regulation of the MEF2C-HDAC5 regulatory axis. Sarcomeres are essential for muscle contractile function. Presently, skeletal muscle disease and dysfunction at the sarcomere level has been asso...

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Detalles Bibliográficos
Autores principales: Ow, Jin Rong, Palanichamy Kala, Monica, Rao, Vinay Kumar, Choi, Min Hee, Bharathy, Narendra, Taneja, Reshma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036183/
https://www.ncbi.nlm.nih.gov/pubmed/27667720
http://dx.doi.org/10.1038/srep34163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036183/
https://www.ncbi.nlm.nih.gov/pubmed/27667720
http://dx.doi.org/10.1038/srep34163

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