Humanization of high-affinity antibodies targeting glypican-3 in hepatocellular carcinoma

Glypican-3 (GPC3) is a cell-surface heparan sulfate proteoglycan highly expressed in hepatocellular carcinoma (HCC). We have generated a group of high-affinity mouse monoclonal antibodies targeting GPC3. Here, we report the humanization and testing of these antibodies for clinical development. We co...

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Detalles Bibliográficos
Autores principales: Zhang, Yi-Fan, Ho, Mitchell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036187/
https://www.ncbi.nlm.nih.gov/pubmed/27667400
http://dx.doi.org/10.1038/srep33878

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036187/
https://www.ncbi.nlm.nih.gov/pubmed/27667400
http://dx.doi.org/10.1038/srep33878

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