Smoothing a rugged protein folding landscape by sequence-based redesign

The rugged folding landscapes of functional proteins puts them at risk of misfolding and aggregation. Serine protease inhibitors, or serpins, are paradigms for this delicate balance between function and misfolding. Serpins exist in a metastable state that undergoes a major conformational change in o...

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Detalles Bibliográficos
Autores principales: Porebski, Benjamin T., Keleher, Shani, Hollins, Jeffrey J., Nickson, Adrian A., Marijanovic, Emilia M., Borg, Natalie A., Costa, Mauricio G. S., Pearce, Mary A., Dai, Weiwen, Zhu, Liguang, Irving, James A., Hoke, David E., Kass, Itamar, Whisstock, James C., Bottomley, Stephen P., Webb, Geoffrey I., McGowan, Sheena, Buckle, Ashley M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036219/
https://www.ncbi.nlm.nih.gov/pubmed/27667094
http://dx.doi.org/10.1038/srep33958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036219/
https://www.ncbi.nlm.nih.gov/pubmed/27667094
http://dx.doi.org/10.1038/srep33958

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