Carbonic anhydrase IV inhibits colon cancer development by inhibiting the Wnt signalling pathway through targeting the WTAP–WT1–TBL1 axis

OBJECTIVE: We found that carbonic anhydrase IV (CA4), a member of the carbonic anhydrases, is silenced in colorectal cancer (CRC). We analysed its epigenetic inactivation, biological effects and prognostic significance in CRC. DESIGN: The biological functions of CA4 were determined by in vitro and i...

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Detalles Bibliográficos
Autores principales: Zhang, Jingwan, Tsoi, Ho, Li, Xiaoxing, Wang, Hua, Gao, Jing, Wang, Kunning, Go, Minnie YY, Ng, Siew C, Chan, Francis KL, Sung, Joseph JY, Yu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Colon
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036249/
https://www.ncbi.nlm.nih.gov/pubmed/26071132
http://dx.doi.org/10.1136/gutjnl-2014-308614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036249/
https://www.ncbi.nlm.nih.gov/pubmed/26071132
http://dx.doi.org/10.1136/gutjnl-2014-308614

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