Predictive Performance of Physiologically Based Pharmacokinetic and Population Pharmacokinetic Modeling of Renally Cleared Drugs in Children

Predictive performance of physiologically based pharmacokinetic (PBPK) and population pharmacokinetic (PopPK) models of drugs predominantly eliminated through kidney in the pediatric population was evaluated. After optimization using adult clinical data, the verified PBPK models can predict 33 of 34...

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Detalles Bibliográficos
Autores principales: Zhou, W, Johnson, TN, Xu, H, Cheung, SYA, Bui, KH, Li, J, Al‐Huniti, N, Zhou, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036422/
https://www.ncbi.nlm.nih.gov/pubmed/27566992
http://dx.doi.org/10.1002/psp4.12101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036422/
https://www.ncbi.nlm.nih.gov/pubmed/27566992
http://dx.doi.org/10.1002/psp4.12101

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