Systematic alanine insertion reveals the essential regions that encode structure formation and activity of dihydrofolate reductase

Decoding sequence information is equivalent to elucidating the design principles of proteins. For this purpose, we conducted systematic alanine insertion analysis to reveal the regions in the primary structure where the sequence continuity cannot be disrupted. We applied this method to dihydrofolate...

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Detalles Bibliográficos
Autores principales: Shiba, Rumi, Umeyama, Mika, Tsukasa, Sayaka, Kamikubo, Hironari, Yamazaki, Yoichi, Yamaguchi, Mariko, Iwakura, Masahiro, Kataoka, Mikio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society of Japan (BSJ) 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036773/
https://www.ncbi.nlm.nih.gov/pubmed/27857587
http://dx.doi.org/10.2142/biophysics.7.1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036773/
https://www.ncbi.nlm.nih.gov/pubmed/27857587
http://dx.doi.org/10.2142/biophysics.7.1

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