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Systematic alanine insertion reveals the essential regions that encode structure formation and activity of dihydrofolate reductase
Decoding sequence information is equivalent to elucidating the design principles of proteins. For this purpose, we conducted systematic alanine insertion analysis to reveal the regions in the primary structure where the sequence continuity cannot be disrupted. We applied this method to dihydrofolate...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Biophysical Society of Japan (BSJ)
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036773/ https://www.ncbi.nlm.nih.gov/pubmed/27857587 http://dx.doi.org/10.2142/biophysics.7.1 |