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Challenges and novel approaches for investigating molecular mediation

Understanding mediation is useful for identifying intermediates lying between an exposure and an outcome which, when intervened upon, will block (some or all of) the causal pathway between the exposure and outcome. Mediation approaches used in conventional epidemiology have been adapted to understan...

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Detalles Bibliográficos
Autores principales: Richmond, R.C., Hemani, G., Tilling, K., Davey Smith, G., Relton, C.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036871/
https://www.ncbi.nlm.nih.gov/pubmed/27439390
http://dx.doi.org/10.1093/hmg/ddw197