Abrogation of immune complex glomerulonephritis by native carboxypeptidase and pharmacological antagonism of the C5a receptor

Activation of complement generates C5a which leads to signaling through C5aR1. This is tightly controlled, including by the plasma proteins factor H (FH) and carboxypeptidase N. Here we studied a chronic serum sickness (CSS) model of glomerulonephritis (GN) in which there is an active humoral immune...

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Detalles Bibliográficos
Autores principales: Alexander, Jessy J., Chaves, Lee D., Chang, Anthony, Dighe, Shruti, Jacob, Alexander, Quigg, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037280/
https://www.ncbi.nlm.nih.gov/pubmed/26166765
http://dx.doi.org/10.1038/cmi.2015.45

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037280/
https://www.ncbi.nlm.nih.gov/pubmed/26166765
http://dx.doi.org/10.1038/cmi.2015.45

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