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Soluble adenylyl cyclase is essential for proper lysosomal acidification
Lysosomes, the degradative organelles of the endocytic and autophagic pathways, function at an acidic pH. Lysosomes are acidified by the proton-pumping vacuolar ATPase (V-ATPase), but the molecular processes that set the organelle’s pH are not completely understood. In particular, pH-sensitive signa...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037342/ https://www.ncbi.nlm.nih.gov/pubmed/27670898 http://dx.doi.org/10.1085/jgp.201611606 |